Before taking any medication or changing medication, all CMT patients should make sure the treating physician is fully aware of their medical condition.
Vinca alkaloids (Vincristine)
Taxols (paclitaxel, docetaxel, cabazitaxel)
Cisplatin & Oxaliplatin
Colchicine (extended use)
Didanosine (ddI, Videx)
Eribulin Mesylate (Halaven)
Metronidazole/Misonidazole (extended use)
Nitrofurantoin (Macrodantin, Furadantin, Macrobid)
Nitrous oxide (inhalation abuse or Vitamin B12 deficiency)
Perhexiline (not used in U.S.)
Pyridoxine (Although megadoses [10 times or more the RDA] of Vitamin B6 may be harmful, high intakes of vitamin B6 from food sources have not been reported to cause adverse effects.)
Stavudine (d4T, Zerit)
Zalcitabine (ddC, Hivid)
Almitrine (not in U.S.)
Cytarabine (high dose)
Tacrolimus (FK506, ProGraf)
Zimeldine (not in U.S.)
Alcohol was removed from the neurotoxic drug list in July 2004. While people with CMT generally suffer no ill effects from the moderate consumption of alcohol, they should be particularly mindful of the fact that alcohol affects balance and coordination, and that overconsumption of alcohol is generally not recommend under any circumstances. If you have questions about alcohol and your health, consult your physician.
Apart from Vincristine, there is no proof that any of these drugs worsen CMT, but if you are concerned, there are plenty of alternatives.
One of our advisers described the situation like this to us:
“If a person unaffected by CMT – ie, at 100% “nerve” capacity – takes one of these drugs, and suffers some neuropathy, and is reduced to 80 or 90% capacity, that is not significant. But if a person with CMT – say at 50% capacity – loses 10% of function, then that’s a significant reduction in function”